ABSTRACT
The research community responded rapidly to the SARS-CoV-2 pandemic with a burst of proteomic studies to understand this new virus. We focus in this chapter on proteomic approaches and advances in the areas of the viral proteome and the viral-host protein-protein interactions exploited to facilitate the pathogenic life cycle of SARS-CoV2. We also outline the proteome and posttranslational protein modifications of infected cells and blood proteomics of COVID-19 patients in relation to pathogenesis, host response, and disease severity. Finally, tools and application for COVID-19 proteomics and implementations in diagnostics and therapies are surveyed before summarizing the present achievements and future perspectives. © 2023 Elsevier Inc. All rights reserved.
ABSTRACT
The COVID-19 crisis has been a challenging and stressful event for individuals with known underlying health problems, not to mention their higher risk of contracting the disease. This phenomenological inquiry was conducted to explore the common self-care practices of the Meranao tribe in the Province of Lanao del Sur, Philippines, concerning their management of hypertension amidst the ongoing pandemic health crisis. This study employed a descriptive-phenomenological approach. Ten known hypertensive adults participated in the study selected using purposive sampling. Data collection employed focus group discussion (FGD) and then analyzed using Colaizzi's approach. Four themes were derived which explained the common practices of the tribe in the self-care management of hypertension amidst the crisis: 1) the use of herbal remedies;2) compliance with prescribed medications;3) dietary control;and 4) remaining physically active. Pa-tients’ strict compliance with known scientific self-care practices in managing hypertension forms a multidimensional strategy in controlling, managing, and preventing hypertension and its related complications. © JKI 2021.
ABSTRACT
In Malaysia, COVID-19 were first detected as imported cases on 25 January and as local infection on 4 February 2020. A surge of positive cases ensued by March 2020 which led to a series of countrywide containment and mitigation measures known as Movement Control Order (MCO). We study the direct effects of MCO on the course of epidemic by analyzing the cumulative and daily infection cases of COVID-19 up to 31 December 2020 in Malaysia and its states using piecewise linear regression and segment neighborhoods algorithm of change-point analysis, respectively. Through piecewise regression on nationwide cases, MCO were likely to almost flatten the epidemic curve in just one month after it was first initiated. While for stateswise cases, the average length of series of concave downward is six months before it turn to concave upward, indicating the period of which deceleration of new cases can be expected. However, the starting of this wave of COVID-19 can be relatively vary for three months in different states and federal territories. Together with change-point analysis on daily cases, the statewise epidemic phases could be subdivided into two to four regimes, whereby the majority of phase transitions fall in April and last quarter of 2020. Overall, the statistical modelling shows that the immediate effect of MCO appears to be effective.
ABSTRACT
The Coronavirus Disease (COVID-19) has caused various unprecedented impacts to the whole world. In relation to this, Malaysia has enforced the Movement Control Over (MCO) starting on 18 March 2020 in order to fight the global COVID-19 pandemic. COVID-19 has claimed hundreds of thousands of lives and caused socio-economic shocks that left no one untouched. The pandemic also has forced all employees, including academicians, to practice Work from Home (WFH). In relation to this, the implementation of e-learning may incur academicians' acceptance that might be influenced by their attitudes towards internet connection, utilizing electronic equipment, and others to ensure an effective e-learning process. This study is aimed to examine the effects of gender, age, and internet competency on internet usage among academicians during the MCO. A total of 223 respondents participated in this study through a purposive sampling method which was conducted among academicians using an online questionnaire. Chi-square analysis was performed to examine the association among genders, age groups, and internet competency with internet usage. The results of the study revealed that there is a significant relationship between the respondents' genders and internet competency on internet usage among academicians during the MCO (χ2 = 0.002, p<0.05). However, it was found that there is no significant relationship between the respondents' age and their internet usage (χ2 = 0.665, p>0.05). In a situation where the country is facing the COVID-19 pandemic and the MCO, the use of the internet has become very important. This study also found that there are differences in internet usage among respondents of different genders and levels of efficiency. But when the online learning method was implemented, all academicians were no exception. Therefore, the age difference of academicians was found not to affect the use of the internet. Future studies by adding more respondents among teachers and those from private institutions are recommended, other than focusing on attitudes and perceptions which will benefit various parties, especially the academicians. © 2021 Author(s).